Nicolas Martin

CNRS RESEARCHER

Office : B222
115 avenue Dr Schweitzer, 33600 Pessac, France
Tel : (+33) 5 56 84 30 20
eMail : nicolas.martin[AT]crpp.cnrs.fr
Google Scholar, ORCID, ResearhGate

RESEARCH INTEREST

Liquid-liquid phase separation / Coacervation / Artificial cells / Stimuli-responsive systems
Member of the BIO 2.0 team

CURRICULUM

Professionnal carrier

Since 2018 : CNRS Researcher
2014-2018 : Post-doctoral research assistant at the University of Bristol (group of Prof. Stephen Mann FRS)
2011-2014 : PhD at ENS Paris (supervised by Dr. Christophe Tribet)

Grants and awards

2025 : ANR PRC PROTOPOLYM (partner)
2024 : ANR PRC SHEILA (partner)
2023 : Doctoral Network SIGSYNCELL (partner)
2023 : Projet RIE U. Bordeaux (coordinator)
2023 : ANR PRC CHEMinDROPS (partner)
2022 : ANR PRC WalLesShape (partner)
2022 : CEFIPRA (coordinator)
2021 : ANR JCJC LASCO2 (coordinator)
2020 : Projet Région Nouvelle-Aquitaine (coordinator)
2019 : ANR PRC CoSyCell (partner)
2018 : IdEx Bordeaux Junior Chair (coordinator)
2018 : Marie Skłodowska-Curie Individual Fellowship (declined)

PUBLICATIONS

  1. E. R. Jimenez Granda, H. Karoui, X. Brilland, J.-C. Baret, N. Martin* Light-responsive mononucleotide coacervates Chem. Eur. J., e202501109 (2025)
  2. C. Xu*, M. Li, N. Martin, S. Mann* Construction of complex bacteriogenic protocells from living material assembly Nat. Protocols (2025)
  3. E. Kluczka, V. Rinaldo, A. Coutable-Pennarun, C. Stines-Chaumeil, J.L.R. Anderson,* N. Martin* Enhanced catalytic activity of a de novo enzyme in a coacervate phase ChemCatChem, 16, e202400558 (2024)
  4. Z. Lin, T. Beneyton, J.-C. Baret, N. Martin* Coacervate droplets for synthetic cells Small Methods, 2300496 (2023)
  5. C. Yin, Z. Lin, X. Jiang, N. Martin, L. Tian* Engineering the coacervate microdroplet Interface via polyelectrolyte and surfactant complexation ACS Appl. Mater. Interfaces, 15, pages 27447-27456 (2023)
  6. T.P. Fraccia*, N. Martin* Non-enzymatic oligonucleotide ligation in coacervate protocells sustains compartment-content coupling Nat. Commun., 14, 2606 (2023)
  7. C. Xu, N. Martin, M. Li,* S. Mann* Living material assembly of bacteriogenic protocells Nature, 609, pages 1029–1037 (2022)
  8. H. Karoui, P.S. Patwal, B.V.V.S.P. Kumar,* N. Martin* Chemical communication in artificial cells: basic concepts, design and challenges Front. Mol. Biosci., 9, 880525 (2022)
  9. N. Coudon, L. Navailles, F. Nallet, I. Ly, A. Bentaleb, J.-P. Chapel, L. Béven, J.-P. Douliez,* N. Martin* Stabilization of all-aqueous droplets by interfacial self-assembly of fatty acids bilayers J. Colloid Int. Sci., 617, 257-266 (2022)
  10. A. Perro, N. Coudon, J.-P. Chapel, N. Martin, L. Béven, J.-P. Douliez* Building micro-capsules using water-in-water emulsion droplets as templates J. Colloid Int. Sci., 613, 681-696 (2022)
  11. N. Martin,* J.-P. Douliez* Fatty acid vesicles and coacervates as model prebiotic protocells ChemSystemsChem, 3, e210004 (2021)
  12. R. Merindol,* N. Martin, T. Beneyton, J.-C. Baret, S. Ravaine Fast and ample light controlled actuation of monodisperse all‐DNA microgels Adv. Funct. Mater., 31, 2010396 (2021)
  13. H. Karoui, M.J. Seck, N. Martin* Self-programmed enzyme phase separation and multiphase coacervate droplet organization Chem. Sci., 12, 2794-2802 (2021)
  14. N. Moreau, N. Martin, P. Gobbo, T.-Y.D. Tang, S. Mann* Spontaneous membrane-less multi-compartmentalisation via aqueous two-phase separation in complex coacervate micro-droplets Chem. Commun., 56, 12717-12720 (2020)
  15. S. Lafon, N. Martin* Reversible photocontrol of DNA coacervation Methods Enzymol., 646, 329-351 (2020)
  16. N. Martin* Dynamic synthetic cells based on liquid–liquid phase separation ChemBioChem, 20, 2553-2568 (2019)
  17. N. Martin,* L. Tian, D. Spencer, A. Coutable‐Pennarun, J.L.R. Anderson, S. Mann* Photoswitchable phase separation and oligonucleotide trafficking in DNA coacervate microdroplets Angew. Chem. Int. Ed., 58, 14594-14598 (2019)
  18. N. Martin, J.-P. Douliez, Y. Qiao, R. Booth, M. Li, S. Mann* Antagonistic chemical coupling in self-reconfigurable host–guest protocells Nat. Commun., 9, 3652 (2018)
  19. J.-P. Douliez,* N. Martin, T. Beneyton, J.-C. Eloi, J.-P. Chapel, L. Navailles, J.-C. Baret, S. Mann, L. Béven Preparation of swellable hydrogel‐containing colloidosomes from aqueous two‐phase Pickering emulsion droplets Angew. Chem. Int. Ed., 57, 7780-7784 (2018)
  20. J.-P. Douliez,* N. Martin, C. Gaillard, T. Beneyton, J.-C. Baret, S. Mann, L. Beven Catanionic coacervate droplets as a surfactant‐based membrane‐free protocell model Angew. Chem. Int. Ed., 56, 13689-13693 (2017)
  21. N. Martin, N. Costa, F. Wien, F.M. Winnik, C. Ortega, A. Herbet, D. Boquet, C. Tribet* Refolding of aggregation‐prone ScFv antibody fragments assisted by hydrophobically modified poly(sodium acrylate) derivatives Macromol. Biosci., 17, 1600213 (2017)
  22. N. Martin, K.P. Sharma, R.L. Harniman, R.M. Richardson, R.J. Hutchings,, D. Alibhai, M. Li, S. Mann* Light-induced dynamic shaping and self-division of multipodal polyelectrolyte-surfactant microarchitectures via azobenzene photomechanics Sci. Rep., 7, 41327 (2017)
  23. L. Tian, N. Martin, P.G. Bassindale, A.J. Patil, M. Li, A. Barnes, B.W. Drinkwater, S. Mann* Spontaneous assembly of chemically encoded two-dimensional coacervate droplet arrays by acoustic wave patterning Nat. Commun., 7, 13068 (2016)
  24. N Martin, M Li, S Mann* Selective uptake and refolding of globular proteins in coacervate microdroplets Langmuir, 32, 5881-5889 (2016)
  25. B. Frka-Petesic, D. Zanchi, N. Martin, S. Carayon, S. Huille, C. Tribet* Aggregation of antibody drug conjugates at room temperature: SAXS and light scattering evidence for colloidal instability of a specific subpopulation Langmuir, 32, 4848-4861 (2016)
  26. N. Martin, J. Ruchmann, C. Tribet* Prevention of aggregation and renaturation of carbonic anhydrase via weak association with octadecyl-or azobenzene-modified poly(acrylate) derivatives Langmuir, 31, 338-349 (2014)
  27. D. Ma, N. Martin, C. Tribet, F.M. Winnik* Quantitative characterization by asymmetrical flow field-flow fractionation of IgG thermal aggregation with and without polymer protective agents Anal. Bioanal. Chem., 406, 7539-7547 (2014)
  28. N. Martin, D. Ma, A. Herbet, D. Boquet, F.M. Winnik, C. Tribet* Prevention of thermally induced aggregation of IgG antibodies by noncovalent interaction with poly (acrylate) derivatives Biomacromolecules, 15, 2952-2962 (2014)
  29. D. Ma, N. Martin, A. Herbet, D. Boquet, C. Tribet, F.M. Winnik* The thermally induced aggregation of immunoglobulin G in solution is prevented by amphipols Chem. Lett., 41, 1380-1382 (2012)