Juan Elezgaray

Current situation: Directeur de recherche CNRS

Contact

Office 124
Paul Pascal Research Center (CRPP), UMR 5031, 115 Avenue Dr. A. Schweitzer 33600 Pessac, France
Tel : (+33) 5 56 84 30 27
Email : juan.elezgaray[AT]crpp.cnrs.fr

Research interest: Self-assembly of nucleic acid systems/ Modelling of electrochemical systems / DNA based nanopores

PROJECTS AND COLLABORATIONS

  • Model of self-assembly of DNA based origamis (collaboration N. Krasnogor, U. Newcastle)
  • Design of DNA based nanopores as biosensors
  • Electrolytes under strong electric field (collaboration C. Drummond, CNRS)
  • Mechanical properties of DNA origamis (collaboration G. Bellot, Montpellier)

PUBLICATIONS (recent)

Optimizing DNA origami assembly through selection of scaffold sequences that minimise off-target interactions, Ben Shirt-Ediss, E. Torelli, Silvia A. Navarro, H. Khamis, A. Kaplan, W. Trewby, J. Elezgaray, N. Moradzadeh-Esmaeili, M Haydell, D. Keppner, M. Famulok, N. Krasnogor
https://www.biorxiv.org/content/10.1101/2025.01.29.635450v1

Driving DNA Nanopore Membrane Insertion through Dipolar Coupling, Yang , LY., Pecastaings, G., Drummond C., Elezgaray J. Nano Letters, 24, 43, 13481-13486 (2024)
DOI: 10.1021/acs.nanolett.4c02302

Reverse engineering DNA origami nanostructure designs from raw scaffold and staple sequence lists, Shirt-Ediss, B., Connolly, J., Elezgaray, J., Torelli, E., Navarro, S. A., Bacardit, J., Krasnogor, N., Comp. Struct. Biotech J., 21, 3615-3626, (2024)
DOI: 10.1016/j.csbj.2023.07.011

Mechanical DNA origami to investigate biological systems, Mills A., Aissaoui, N ., Finkel, J., Elezgaray, J., Bellot, G. Advanced Biology 7, (2023)
DOI: 10.1002/adbi.202200224

A modular spring-loaded actuator for mechanical activation of membrane proteins, Mills, A., Aissaoui, N., Maurel, D., Elezgaray, J., Morvan, F., Vasseur, JJ, Margeat, E., Quast, RB, Kee-Him, JL, Saint, N., Benistant, C., Nord, A., Pedaci, F., Bellot, G. Nat. Comm. 13, 3182 (2022)
DOI: 10.1038/s41467-022-30745-2

Detection of short DNA sequences with DNA nanopores, Yang, LY, Cullin, C., Elezgaray, J. ChemPhysChem e202200021 (2022)
DOI: 10.1002/cphc.202200021